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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinopathy of prematurity (ROP)
ncRNA name VEGF siRNA
ncRNA Category siRNA
Disease name retinopathy of prematurity (ROP)
Species Homo sapiens
Tissues/Cell_line immature fetal retinal microvascular endothelial cells
Methods siRNA transfection, RT-PCR, Western blot, MTT assay
Expression pattern associated
Functional description VEGF siRNA could down-regulate the expression of VEGF in immature fetal retinal microvascular endothelial cells and suppressed cell proliferation. Application of siRNA to inhibit expression of VEGF may be a hopeful way to prevent and cure ROP.
PubMed ID 19951475
Year 2009
Title Effect of vascular endothelial growth factor small interfering RNA (siRNA) on retinal microvascular endothelial cells under hypoxia condition in vitro.
Drug-related ncRNA NO

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